Artikel Dosen
The Preliminary Study on Safety of Using Mangosteen Peel Extract as Natural Herbs
- Bagikan:
Background: The properties of mangosteen skin as anti-inflammatory have been described by many
researchers both in vitro and in vivo. Over the past few years, mangosteen peel extract is used as a natural
herbal remedy either orally or topically. However, the potential toxicity of extracts and formulations
containing mangosteen peels is still a matter of little concern.
Objective: To prove that mangosteen skin extract is safe to use as natural herbal medicine. Methods:
Experiments with laboratory tests of microbiological tests and acute toxicity tests with samples of 30 Balb /
C mice aged 8-10 weeks weight 25-35 g, divided into 6 groups in which 5 groups of intervention (giving
mangosteen skin extract) with different dose (5, 50, 300, 2000 and 5000 mg / kgBB) and 1 control group.
Parameters observed included weight, motor activity, salivation, respiration, defecation, urination,
piloerection every day for 14 days while the observed organ was liver. Behavioral data and organ test
results were used to evaluate the toxic effects of mangosteen skin extract. Data was analyzed with ANOVA
and Post Hoc Test.
Results: Most subjects' mean body weight from day 0 to day 14 tended to stabilize with a slight increase or
decrease of less than 1%. The results of observation for 14 days after the intervention to each group there
was no death and no effect on the motor system, saliva, respiration, defecation, urination and piloerection
and did not happen itch allergies. Based on Post Hoc Test (LSD), there was no significant difference in
mean liver weight group with highest dose (5000 mg / kgBB) and control group.
Conclusion: Extract of mangosteen skin with dosage ≤ 5000 mg/kg BW is not toxic and safe to use as
natural herbal medicine.
Informasi Detail
| Pernyataan Tanggungjawab | |
|---|---|
| Pengarang |
Lanny Sunarjo - Pengarang Utama
Suharti - Pengarang Tambahan Oedijani - Pengarang Tambahan Henry Setyawan Susanto - Pengarang Tambahan |
| NIM | |
| Bahasa |
Indonesia
|
| Deskripsi Fisik |
6 p.
|
| Dilihat sebanyak |
1107
|
| Penerbit | Journal of Medical Science And clinical Research : India., 2017 |
|---|---|
| Edisi |
JMSCR Volume 05 Issue 07 July 2017
|
| Subjek | |
| Klasifikasi |
081
|